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Members of the McMaster Ancient DNA Centre are involved in many different research projects.

Browse some of our research projects below.

HIV: Origins and Evolution

Using DNA from archival specimens to study the origins and evolution of HIV: implications for the design of more effective vaccines

Team members involved: Melanie Kuch and Debi Poinar
Previous team members involved: Michael Bunce, John Okello
Project also in collaboration with Ken Rosenthal
Funding provided by: CIHR (Canadian Institutes of Health Research)

Learn more about HIV: Origins and Evolution

Black Death (Yersinia pestis) genomics

Ancient Epidemiology and Bacterial Physiology of the Black Death Pathogen

Team members involved: Jennifer Klunk, Melanie Kuch, Katherine Eaton
Former team members involved: Kirsti Bos
Project also in collaboration with Johannes Krause, Verena Schuenemann, Sharon DeWitte
Funding provided by: CIHR (Canadian Institutes of Health Research)

Learn more about Black Death genomics

Cholera (Vibrio cholerae): evolution of a pandemic

Bacterial genomics of 19th century cholera in North America

Team members involved: Alison Devault
Project also in collaboration with Joseph Tien, David Earn, David Fisman, Anna Dhody of the Mütter Museum
Funding provided by: CIHR (Canadian Institutes of Health Research)

Learn more about Cholera (Vibrio cholerae): evolution of a pandemic

Proboscidean Phylogeography in North America

Using Mammoth and Mastodon Population Genetics to Track Pleistocene Ecosystems

Team members involved: Emil Karpinski
Former Team Members: Regis Debruyne, Genevieve Chu, Ben Novak, Jacob Enk, Jocelyn Ip
Project also in collaboration with Ross D.E. Macphee, Dan Fisher, Grant Zazula, Dale Guthrie and Cerpolex/Mammuthus
Funding provided by: NSERC (National Sciences and Engineering Research Council of Canada)

Learn more about Proboscidean Phylogeography in North America

Xenarthran phylogenetics and evolution

Reconstructing the unique evolutionary history of armadillos, anteaters, and sloths

Team members involved: Melanie Kuch, Jonathan Hughes
Project in collaboration with Frédéric Delsuc, Gillian Gibb
Funding provided by: NSERC (National Sciences and Engineering Research Council of Canada)
CNRS (Centre National de la Recherche Scientifique) and Scientific council of the Université Montpellier 2.

Learn more about Xenarthran phylogenetics and evolution

Packrat (Neotoma) Midden Metagenomics

Reconstructing Paleoenvironmental and Ecological Change in the US Southwest Using DNA from Ancient Packrat Middens

Team members involved: Melanie Kuch, Angela Hornsby
Collaboration with Julio Betancourt (University of Arizona), Felisa Smith (University of New Mexico), Jim Patton (University of California, Berkeley), and Marjorie Matocq (University of Nevada, Reno)

Learn more about Packrat (Neotoma) Midden Metagenomics

Ancient DNA Repair

Team members involved: Nathalie Mouttham
Former team members involved: Carsten Schwarz
Collaboration with Michael Weinfeld (Cross Cancer Institute – University of Alberta) and Roger Woodgate (Laboratory of Genomic Integrity – National Institutes of Health, Bethesda, Maryland)
Funding provided by: NSERC (National Sciences and Engineering Research Council of Canada)

 

Learn more about Ancient DNA Repair