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Poinar Hendrik, Professor

Biography

Research & Supervisory Interests


I am a molecular evolutionary geneticist and biological anthropologist by training, and rely heavily on interdisciplinary research. I use both chemical and molecular techniques to elucidate the state of preservation within forensic, archeological and paleontological remains. This information is subsequently used to devise novel techniques to extract the molecular information (DNA, RNA and/or protein sequences) and use it to address anthropological questions, such as the identification of pathogens responsible for past pandemics (i.e. The Black Death, The Plague of Justinian) as well as the evolutionary dynamics of infectious disease (i.e. Vibrio cholera).

Education

PhD Ludwig Maximillian Universität Münich, 1999

Teaching

Search course offerings in Anthropology

 

Courses (2018-19)

Fall

  • Anthrop 2U03 - Plagues and People   

Winter

  • On Research Leave

Courses (2017-18)

Fall

  • ANTHROP 2U03 - Plagues and People   
  • Acting Chair for the Department of Anthropology 

Winter

  • On Research Leave

 

Research

Selected Publications

2017 Karpinski, E., Mead, J. I. & Poinar, H. N. Molecular identification of paleofeces from Bechan Cave, southeastern Utah, USA. Quat. Int. 443, 140–146.

2017  Ana T. Duggan, Maria F. Perdomo, Dario Piombino-Mascali, Stephanie Marciniak, Debi Poinar, Matthew V. Emery, Jan P. Buchmann, Sebastian Duchêne, Rimantas Jankauskas, Margaret
Humphreys, G. Brian Golding, John Southon, Alison Devault, Jean-Marie Rouillard, Jason W. Sahl, Olivier Dutour, Klaus Hedman, Antti Sajantila, Geoffrey L. Smith, Edward C. Holmes
Hendrik Poinar. 17th Century Variola Virus Reveals the Recent History of Smallpox. Current Biology 26(24) p3407-3412.

2017 Dan Chang, Michael Knapp, Jacob Enk, Matthias Meyer, Sebastian Lippold, Martin Kircher, Adrian Lister, Ross D. E. MacPhee, Paul Czechowski, Robert Sommer, Emily Hodges, Nikolaus
Stümpel, Ian Barnes, Love Dalén, Anatoly Derevianko, Mietje Germonpré, Alexandra Hillebrand-Voiculescu, Silviu Constantin, Tatyana Kuznetsova, Dick Mol, Thomas Rathgeber, Wilfried
Rosendahl, Alexey N. Tikhonov, Eske Willerslev, Greg Hannon, Carles Lalueza-Fox, Ulrich Joger, Hendrik Poinar, Michael Hofreiter, Beth Shapiro. The evolutionary and phylogeographic
history of woolly mammoths: a comprehensive mitogenomic analysis. Nature Scientific Reports 44585 (2017); doi :10.1038/srep44585.

2017 Alison M. Devault, Tatum D. Mortimer, Andrew Kitchen, Henrike Kiesewetter, Jacob M. Enk, G. Brian Golding, John Southon, Melanie Kuch, Ana T. Duggan, William Aylward, Shea N. Gardner, Jonathan E. Allen, Andrew M. King, Gerard D. Wright, Makoto Kuroda, Kengo Kato, Derek E. G. Briggs, Gino Fornaciari, Edward C. Holmes, Hendrik N. Poinar, Caitlin S. Pepperell. A
molecular portrait of maternal sepsis from Byzantine Troy. eLife 2017;6:e20983.

2016 Dang U.J., Devault A.M., Mortimer T.D., Pepperell C.S., Poinar H.N., Golding G.B. Estimation of Gene Insertion/Deletion Rates with Missing Data. Genetics. 2016, 204(2):513-529.

Kirsten I. Bos, Alexander Herbig, Jason Sahl, Nicholas Waglechner, Mathieu Fourment, Stephen A. Forrest, Jennifer Klunk, Debi Poinar, Melanie Kuch, G. Brian Golding, Verena J. Schuenemann, Olivier Dutour, Paul Keim, David M. Wagner, Edward C. Holmes, Johannes Krause, and Hendrik N. Poinar. Yersinia pestis genomes from an 18th century mass burial in France reveals the longterm persistence of plague in Europe during the second pandemic. eLife (http://dx.doi.org/10.7554/eLife.12994).

2016 Enk, J., Devault, A., Widga, C, Saunders, J., Spazk, P., Zazula, G., Macphee, R., Froese, D., Fisher, D., and H.N. Poinar, 2016. Complete mitogenome phylogeography of Mammuthus from southern North America suggests a deep interspecific chronology. Frontiers in Ecology and Evolution http://dx.doi.org/10.3389/fevo.2016.00042.

2016 Palkopoulou, E., Mallick, S., Skoglund, P., Enk, J., Rohland, N., Li, H., Omrak, A., Vartanyan, S., Poinar, H., Götherström, A., Reich, D., Dalén. L., Heterochronous woolly mammoth genomes reveal demographic and genetic declines. 2016, Current Biology, 25 (10):1395-1400.

2016 Frédéric Delsuc, Gillian C. Gibb, Melanie Kuch, Guillaume Billet, Lionel Hautier, John Southon, Jean-Marie Rouillard, Juan Carlos Fernicola, Sergio F. Vizcaíno, Ross D. E. MacPhee, Hendrik N. Poinar. The phylogenetic affinities of the extinct glyptodonts, 2016 Current Biology 22;26(4):R155-6. doi: 10.1016/j.cub.2016.01.039.

2016 Soares AER, Novak B, Haile J, Fjeldså J, GIlbert MTP, Poinar H, Church G, Shapiro B Complete mitochondrial genomes of living and extinct pigeons revise the timing of the columbiform
radiation BMC Evolutionary Biology 16: 1-9 (2016) pdf

2015 Gillian C. Gibb, Fabien L. Condamine, Melanie Kuch, Jacob Enk, Nadia Moraes-Barros, Mariella Superina, Hendrik N. Poinar and Frédéric Delsuc. 2015 Shotgun Mitogenomics Provides a
Reference Phylogenetic Framework and Timescale for Living Xenarthrans. Molecular Biology and Evolution, 33(3):621-42. doi: 10.1093/molbev/msv250

2015 Marciniak, S., Klunk, J., Devault, A., Enk, J., Poinar, H., Ancient DNA in the Genomic Era: Reconstructing Human Evolutionary Pathways, 2015. Journal of Human Evolution 79:21-34. doi:
10.1016/j.jhevol.2014.11.003.

2015 Mouttham N, Klunk J, Kuch M, Fourney R, Poinar H. Surveying the repair of ancient DNA from 9 bones via high-throughput sequencing. Biotechniques. 2015 Jul 1;59(1):19-25. doi:
10.2144/000114307

2014 Gutierrez-Garcia, T.A., Vazquez-Dominguez, E., Arroyo-Cabrales, J., Kuch, M., Enk, J., King, C., and H. N. Poinar, 2014. Ancient DNA and the Tropics: a rodent’s tale. Biology Letters (Roy Soc).10:20140224. (http://dx.doi.org/10.1098/rsbl.2014.0224)

2014 Devault, A.M., Golding, G.B., Waglechner, N., Enk, J., Kuch, M., Tien, J., Shi, M., Fisman, D., Dhody, A.D., Forrest, S., Bos, K., Earn, D.J.D., Holmes, E.D., and H.N. Poinar, 2014. A ‘Classical’ genome for the second pandemic strain of Vibrio cholerae, Philadelphia, 1849. New England Journal of Medicine, 370(4):334-40.

2014 Devault, A., Jaing, C., Gardner, S., Porter. T.M., Enk, J., Thissen, J., Allen, J., Borucki, M., DeWitte, S., Dhody, A., McLoughin, K., and H.N Poinar, 2014. Ancient pathogen DNA in
archaeological samples detected with a Microbial Detection Array. Nature Scientific Reports doi:10.1038/srep04245.

2014 Wagner, D., Klunk, J., Harbeck, M., Devault, A., Waglechner, N., Sah, J.W., Enk, J., Birdsell, D., Kuch, M., Lumibao, C.J., Poinar, D., Pearson, T., Fourment, M., Golding, B., Riehm, J.,. Earn, D.J., DeWitte, S., Rouillard, J.M., Grupe, G., Wiechmann, I., Bliska, J.B., Keim, P., Scholz, H., Holmes, E., and H.N. Poinar, 2014. The Plague of Justinian was caused by a ‘dead-end’ emergence of Yersinia pestis. The Lancet Infectious Disease (doi: 10.1016/S1473-3099(13)70323-2.).

2014 Palkopoulou, E., Mallick, S., Skoglund, P., Enk, J., Rohland, N., Li, H., Omark, A., Vartanyan, S., Poinar, H., Götherström, A., Reich, D., Dalén, L., Hetereochronous woolly mammoth genomes reveal demographic and genetic declines. Nature.  

2014 Marciniak, S., Klunk, J., Davault, A., Enk, J., Poinar, H., Ancient DNA in the Genomic Era: Reconstructing Human Evolutionary Pathways. Journal of Human Evolution.

2014 Enk, J., Devault, A., Widga, C., Saunders, J., Spazk, P., Zaxula, G., Macphee, R., Froese, D., Fisher, D., and  H.N. Poinar. Complete mitogenome phylogeography of Mammuthus from southern North America suggests a deep interspecific chronology. Molecular Ecology.

2014 Gutierrez-Garcia, T.A., Vazquez-Dominguez, E., Arroyo-Cabrales, J., Kuch, M., Enk, J., King, C., and H.N. Poinar. Ancient DNA and the Tropics: a rodent’s tale. Biology Letters (Roy Soc). 10: 20140224 (http://dx.doi.org/10.10098/rbsl.2014.0224)

2014 Devault, A.M., Golding, G.B., Waglechner, N., Enk, J., Kuch, M., Tien, J., Shi, M., Fisman, D., Dhody, A.D., Forrest, S., Bos, K., Earn, D.J.D., Holmes, E.D., and H.N. Poinar.  A ‘Classical’ genome for the second pandemic strain of Vibrio cholerae, Philadelphia, 1849. New England Journal of Medicine, 370(4):334-40.

2014 Devault, A., Jaing, C., Gardner, S., Porter. T.M., Enk, J., Thissen, J., Allen, J., Borucki, M., DeWitte, S.,  Dhody, A., McLoughin, K., and H.N Poinar. Ancient pathogen DNA in archaeological samples detected with a Microbial Detection Array. Nature Scientific Reports doi:10.1038/srep04245.

2014 Wagner, D., Klunk, J., Harbeck, M., Devault, A., Waglechner, N., Sah, J.W., Enk, J., Birdsell, D., Kuch, M., Lumibao, C.J., Poinar, D., Pearson, T., Fourment, M., Golding, B., Riehm, J.,. Earn, D.J., DeWitte, S., Rouillard, J.M., Grupe, G., Wiechmann, I., Bliska, J.B., Keim, P., Scholz, H., Holmes, E., and H.N. Poinar, 2014.  The Plague of Justinian was caused by a ‘dead-end’ emergence of Yersinia pestis. The Lancet Infectious Disease (doi: 10.1016/S1473-3099(13)70323-2.).

2014 Enk, J., Devault, A., Kuch, M., Murgha, Y., Rouillard, J.M., and H.N. Poinar. Ancient Whole Genome Enrichment Using Modern DNA-Derived Baits. Molecular Biology and Evolution (231 (5): 1292-1294.

2011 Enk, J., Debruyne, R., Devault, A. King, C., Treagen,T., O’Rourke, D., Salzberg, S., Fisher, D., MacPhee, R., and Hendrik Poinar 2011. Columbian Mammoth Mitogenome  Suggests  Interbreeding  with Woolly  Mammoths. Genome Biology, doi:10.1186/gb-2011-12-5-r51

2011 Bos, K., Schuenemann, V., Golding, B., Burbano, H., Waglechner, N., Coombes, B., McPhee, J., DeWitte, S., Meyer, M., Schmedes, S., Wood, J., Earn, S., Herring, A., Bauer, P., Poinar, H.N. and Johannes Krause, 2011. A draft genome of Yersinia pestis from victims of the Black Death, Nature 478, 506–510.

2011. Herald waves of cholera in 19th century London. (with Tien, J., Fisman, D., and Earn, D.) Journal of the Royal Society Interface 8(58), 756-760.

2011. Ancient DNA from lake sediments: bridging the gap between palaeoecology and genetics. (with Anderson-Carpenter, L.L., McLachlan, J.S., Jackson, S.T., Kuch, M., and Lumibao, C.) BMC Evolutionary Biology11:30 1-15.

2010. A quantitative assessment of the sensitivity of various commercially available reverse transcriptases on low copy number RNA levels. (with Okello, J.B.A., Rodriquez, L., Poinar, D., Bos, K., Okwi, A.L., Bimenya, G.S., Sewankambo, N.K., Henry, K.R., and Kuch, M.) PLOS-ONE 5(11), e13931.

2010. A quantitative and qualitative comparison of total nucleic acid (DNA and RNA) yields from formalin-fixed paraffin-embedded tissues using ten different extraction methods. (with Okello, J., Zurek, J., Devault A., Kuch, M., Okwi, A.L., Wewankambo, N., Bimenya, G., and Poinar, D.) Analytical Biochemistry 400(1), 110-117.

2010. Regional differences in bone collagen d13C and d15N of Pleistocene mammoths: implications for palaeoecology of mammoth steppe. (with Szpak, P., Grocke, D., Debruyne, R., MacPhee, R., Guthrie, D., Froese, D., and Zazula, G.)Palaeogeography, Palaeoclimatology, and Palaeoecology 286, 88-96.

2009. A quantitative approach to detect and overcome PCR inhibition in ancient DNA extracts. (with King, C., Debruyne, R., Kuch, M., and Schwarz C.) Biotechniques 47(5), 351-356.

2009. New insights from old bones: DNA preservation and degradation in permafrost preserved mammoth remains. (with Schwarz, C., Debruyne, R., Kuch, M., McNally, E., Schwarcz, H., Aubrey, A., and Bada, J.) Nucleic Acids Research 37(10), 3215-3229.

2009. Time-dependency of molecular rates in ancient DNA datasets, a sampling artefact? (with Debruyne, R.) Systematic Biology58(3),348-60

2003. Molecular caving. (with Hofrieter, M., Mead J., and Martin, P.S.) Current Biology. 13, 693-695.

2003. Nuclear gene sequences from a Late Pleistocene sloth coprolite. (with Kuch, M., McDonald, G., Martin, P.S. and Paabo, S.)Current Biology 13, 1150-1152.

2002. The genetic secrets some fossils hold. Accounts of Chemical Research, 35, 676-84.

2001. Molecular analyses of oral polio vaccine samples. (with Kuch, M. and Paabo, S.) Science 292, 743-744.

2001. A molecular analyses of the dietary diversity for three archaic native americans. (With Kuch, M., Sobolik, K., Barnes, I., Stankiewicz, B.A., Spaulding, G., Bryant, V., Cooper, A. & Paabo S.) Proceedings of the National Academy of Sciences USA 98, 4317-4322.

2000. Ancient DNA: Do it right or not at all. (with A. Cooper) Science 289, 1139.

1998. Molecular Coproscopy: Dung and Diet from of the extinct ground sloth Nothrotheriops shastensis. (with Hofreiter, M., Spaulding, G., Martin, P.S., Stankiewicz, A. B., Bland, H. Evershed, R. P., Possnert, G., Paabo, S.) Science 281, 402-406.